Results of a Randomized Trial of Chlorambucil Versus Fludarabine for Patients With Untreated Waldenström Macroglobulinemia, Marginal Zone Lymphoma, or Lymphoplasmacytic Lymphoma
Identifieur interne : 004C96 ( Main/Exploration ); précédent : 004C95; suivant : 004C97Results of a Randomized Trial of Chlorambucil Versus Fludarabine for Patients With Untreated Waldenström Macroglobulinemia, Marginal Zone Lymphoma, or Lymphoplasmacytic Lymphoma
Auteurs : Véronique Leblond [France] ; Steve Johnson [Royaume-Uni] ; Sylvie Chevret [France] ; Adrian Copplestone [Royaume-Uni] ; Simon Rule [Royaume-Uni] ; Olivier Tournilhac [France] ; John Francis Seymour [Australie] ; Russell D. Patmore [Royaume-Uni] ; David Wright [Royaume-Uni] ; Pierre Morel [France] ; Marie-Sarah Dilhuydy [France] ; Sara Willoughby [Royaume-Uni] ; Caroline Dartigeas [France] ; Marion Malphettes [France] ; Bruno Royer [France] ; Maeve Ewings [Royaume-Uni] ; Guy Pratt [Royaume-Uni] ; Julie Lejeune [France] ; Florence Nguyen-Khac [France] ; Sylvain Choquet [France] ; Roger G. Owen [Royaume-Uni]Source :
- Journal of clinical oncology [ 0732-183X ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Purpose Treatment options for patients with Waldenström macroglobulinemia (WM) and closely related disorders include alkylating agents, purine analogs, and monoclonal antibodies. No large randomized studies have yet been reported comparing any of these approaches. Patients and Methods The randomized WM1 study (Trial Comparing Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia) was undertaken in 101 centers in five countries enrolling 414 eligible patients (339 with WM, 37 with non-mucosa-associated lymphoid tissue marginal zone lymphoma, and 38 with lymphoplasmacytic lymphoma) who were randomly assigned to receive chlorambucil or fludarabine. The primary end point was the overall response rate (ORR). Results On the basis of intent-to-treat analysis, the ORR was 47.8% (95% CI, 40.9% to 54.8%) in the fludarabine arm versus 38.6% (95% CI, 32.0% to 45.7%) in the chlorambucil arm (P = .07). With a median follow-up of 36 months (interquartile range, 18 to 58 months), median progression-free survival (PFS), and duration of response (DR) were significantly improved in the fludarabine arm compared with the chlorambucil arm: PFS, 36.3 versus 27.1 months (P = .012) and DR, 38.3 versus 19.9 months (P < .001). In patients with WM, median overall survival (OS) was not reached in the fludarabine arm versus 69.8 months in the chlorambucil arm (95% CI, 61.6 to 79.8 months; P = .014). Grade 3 to 4 neutropenia was significantly higher among patients treated with fludarabine (36%) compared with patients treated with chlorambucil (17.8%; P < .001). Second malignancies were significantly more frequent in the chlorambucil arm with 6-year cumulative incidence rate of 20.6% versus 3.7% in the fludarabine arm (P = .001). Conclusion In the complete intent-to-treat study population, fludarabine significantly improved PFS compared with chlorambucil, and in patients with WM, it improved OS.
Affiliations:
- Australie, France, Royaume-Uni
- Angleterre, Aquitaine, Auvergne (région administrative), Auvergne-Rhône-Alpes, Centre-Val de Loire, Hauts-de-France, Midlands de l'Ouest, Nord-Pas-de-Calais, Nouvelle-Aquitaine, Picardie, Région Centre, Victoria (État), Île-de-France
- Amiens, Birmingham, Bordeaux, Clermont-Ferrand, Lens (Pas-de-Calais), Melbourne, Paris, Tours
- Université de Melbourne
Links toward previous steps (curation, corpus...)
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type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Nguyen Khac, Florence" sort="Nguyen Khac, Florence" uniqKey="Nguyen Khac F" first="Florence" last="Nguyen-Khac">Florence Nguyen-Khac</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hopital Pitié-Salpêtriere, Assistance Publique-Hopitaux de Paris (AP-HP), Université Paris 6</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Université Paris 6</wicri:noRegion><wicri:noRegion>Hopital Pitié-Salpêtriere, Assistance Publique-Hopitaux de Paris (AP-HP), Université Paris 6</wicri:noRegion></affiliation></author><author><name sortKey="Choquet, Sylvain" sort="Choquet, Sylvain" uniqKey="Choquet S" first="Sylvain" last="Choquet">Sylvain Choquet</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hopital Pitié-Salpêtriere, Assistance Publique-Hopitaux de Paris (AP-HP), Université Paris 6</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Université Paris 6</wicri:noRegion><wicri:noRegion>Hopital Pitié-Salpêtriere, Assistance Publique-Hopitaux de Paris (AP-HP), Université Paris 6</wicri:noRegion></affiliation></author><author><name sortKey="Owen, Roger G" sort="Owen, Roger G" uniqKey="Owen R" first="Roger G." last="Owen">Roger G. Owen</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>St. James's University Hospital</s1><s2>Leeds</s2><s3>GBR</s3><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>St. James's University Hospital</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0117659</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0117659 INIST</idno><idno type="RBID">Pascal:13-0117659</idno><idno type="wicri:Area/PascalFrancis/Corpus">000B64</idno><idno type="wicri:Area/PascalFrancis/Curation">005301</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000667</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000667</idno><idno type="wicri:doubleKey">0732-183X:2013:Leblond V:results:of:a</idno><idno type="wicri:Area/Main/Merge">004E41</idno><idno type="wicri:Area/Main/Curation">004C96</idno><idno type="wicri:Area/Main/Exploration">004C96</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Results of a Randomized Trial of Chlorambucil Versus Fludarabine for Patients With Untreated Waldenström Macroglobulinemia, Marginal Zone Lymphoma, or Lymphoplasmacytic Lymphoma</title><author><name sortKey="Leblond, Veronique" sort="Leblond, Veronique" uniqKey="Leblond V" first="Véronique" last="Leblond">Véronique Leblond</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hopital Pitié-Salpêtriere, Assistance Publique-Hopitaux de Paris (AP-HP), Université Paris 6</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Université Paris 6</wicri:noRegion><wicri:noRegion>Hopital Pitié-Salpêtriere, Assistance Publique-Hopitaux de Paris (AP-HP), Université Paris 6</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Steve" sort="Johnson, Steve" uniqKey="Johnson S" first="Steve" last="Johnson">Steve Johnson</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Taunton and Somerset National Health Service (NHS) Trust</s1><s2>Taunton</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Taunton and Somerset National Health Service (NHS) Trust</wicri:noRegion></affiliation></author><author><name sortKey="Chevret, Sylvie" sort="Chevret, Sylvie" uniqKey="Chevret S" first="Sylvie" last="Chevret">Sylvie Chevret</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Hôpital Saint-Louis, AP-HP</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Copplestone, Adrian" sort="Copplestone, Adrian" uniqKey="Copplestone A" first="Adrian" last="Copplestone">Adrian Copplestone</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Plymouth Hospitals NHS Trust</s1><s2>Plymouth</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Plymouth Hospitals NHS Trust</wicri:noRegion></affiliation></author><author><name sortKey="Rule, Simon" sort="Rule, Simon" uniqKey="Rule S" first="Simon" last="Rule">Simon Rule</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Plymouth Hospitals NHS Trust</s1><s2>Plymouth</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Plymouth Hospitals NHS Trust</wicri:noRegion></affiliation></author><author><name sortKey="Tournilhac, Olivier" sort="Tournilhac, Olivier" uniqKey="Tournilhac O" first="Olivier" last="Tournilhac">Olivier Tournilhac</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Hopital Universitaire Estaing, Clermont-Ferrand Université Auvergne, Clermont-Ferrand</s1><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Francis Seymour, John" sort="Francis Seymour, John" uniqKey="Francis Seymour J" first="John" last="Francis Seymour">John Francis Seymour</name><affiliation wicri:level="4"><inist:fA14 i1="15"><s1>Peter MacCallum Cancer Centre, and University of Melbourne</s1><s2>Victoria</s2><s3>AUS</s3><sZ>7 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Patmore, Russell D" sort="Patmore, Russell D" uniqKey="Patmore R" first="Russell D." last="Patmore">Russell D. Patmore</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Hull and East Yorkshire Hospitals NHS Trust</s1><s2>Hull</s2><s3>GBR</s3><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Hull and East Yorkshire Hospitals NHS Trust</wicri:noRegion></affiliation></author><author><name sortKey="Wright, David" sort="Wright, David" uniqKey="Wright D" first="David" last="Wright">David Wright</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Mid Yorkshire Hospitals NHS Trust</s1><s2>Pontefract</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Mid Yorkshire Hospitals NHS Trust</wicri:noRegion></affiliation></author><author><name sortKey="Morel, Pierre" sort="Morel, Pierre" uniqKey="Morel P" first="Pierre" last="Morel">Pierre Morel</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Hopital Schaffner</s1><s2>Lens</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lens (Pas-de-Calais)</settlement></placeName></affiliation></author><author><name sortKey="Dilhuydy, Marie Sarah" sort="Dilhuydy, Marie Sarah" uniqKey="Dilhuydy M" first="Marie-Sarah" last="Dilhuydy">Marie-Sarah Dilhuydy</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Centre Hospitalier Universitaire (CHU) Haut Leveque</s1><s2>Bordeaux</s2><s3>FRA</s3><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Willoughby, Sara" sort="Willoughby, Sara" uniqKey="Willoughby S" first="Sara" last="Willoughby">Sara Willoughby</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Wye Valley NHS Trust</s1><s2>Hereford</s2><s3>GBR</s3><sZ>12 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Wye Valley NHS Trust</wicri:noRegion></affiliation></author><author><name sortKey="Dartigeas, Caroline" sort="Dartigeas, Caroline" uniqKey="Dartigeas C" first="Caroline" last="Dartigeas">Caroline Dartigeas</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>CHU de Tours</s1><s2>Tours</s2><s3>FRA</s3><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Malphettes, Marion" sort="Malphettes, Marion" uniqKey="Malphettes M" first="Marion" last="Malphettes">Marion Malphettes</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Hôpital Saint-Louis, AP-HP</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Royer, Bruno" sort="Royer, Bruno" uniqKey="Royer B" first="Bruno" last="Royer">Bruno Royer</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>CHU</s1><s2>Amiens</s2><s3>FRA</s3><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Picardie</region><settlement type="city">Amiens</settlement></placeName></affiliation></author><author><name sortKey="Ewings, Maeve" sort="Ewings, Maeve" uniqKey="Ewings M" first="Maeve" last="Ewings">Maeve Ewings</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Taunton and Somerset National Health Service (NHS) Trust</s1><s2>Taunton</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Taunton and Somerset National Health Service (NHS) Trust</wicri:noRegion></affiliation></author><author><name sortKey="Pratt, Guy" sort="Pratt, Guy" uniqKey="Pratt G" first="Guy" last="Pratt">Guy Pratt</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Heart of England NHS Foundation Trust</s1><s2>Birmingham</s2><s3>GBR</s3><sZ>17 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Lejeune, Julie" sort="Lejeune, Julie" uniqKey="Lejeune J" first="Julie" last="Lejeune">Julie Lejeune</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Hôpital Saint-Louis, AP-HP</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Nguyen Khac, Florence" sort="Nguyen Khac, Florence" uniqKey="Nguyen Khac F" first="Florence" last="Nguyen-Khac">Florence Nguyen-Khac</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hopital Pitié-Salpêtriere, Assistance Publique-Hopitaux de Paris (AP-HP), Université Paris 6</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Université Paris 6</wicri:noRegion><wicri:noRegion>Hopital Pitié-Salpêtriere, Assistance Publique-Hopitaux de Paris (AP-HP), Université Paris 6</wicri:noRegion></affiliation></author><author><name sortKey="Choquet, Sylvain" sort="Choquet, Sylvain" uniqKey="Choquet S" first="Sylvain" last="Choquet">Sylvain Choquet</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Hopital Pitié-Salpêtriere, Assistance Publique-Hopitaux de Paris (AP-HP), Université Paris 6</s1><s3>FRA</s3><sZ>1 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Université Paris 6</wicri:noRegion><wicri:noRegion>Hopital Pitié-Salpêtriere, Assistance Publique-Hopitaux de Paris (AP-HP), Université Paris 6</wicri:noRegion></affiliation></author><author><name sortKey="Owen, Roger G" sort="Owen, Roger G" uniqKey="Owen R" first="Roger G." last="Owen">Roger G. Owen</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>St. James's University Hospital</s1><s2>Leeds</s2><s3>GBR</s3><sZ>21 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>St. James's University Hospital</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of clinical oncology</title><title level="j" type="abbreviated">J. clin. oncol.</title><idno type="ISSN">0732-183X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of clinical oncology</title><title level="j" type="abbreviated">J. clin. oncol.</title><idno type="ISSN">0732-183X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic agent</term><term>B cell neoplasm</term><term>Cancerology</term><term>Chlorambucil</term><term>Chronic</term><term>Clinical trial</term><term>Comparative study</term><term>Fludarabine</term><term>Human</term><term>Immunocytoma</term><term>Marginal zone lymphoma</term><term>Randomization</term><term>Waldenström macroglobulinemia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chlorambucil</term><term>Essai clinique</term><term>Randomisation</term><term>Fludarabine</term><term>Etude comparative</term><term>Homme</term><term>Macroglobulinémie de Waldenström</term><term>Cancérologie</term><term>Lymphome de la zone marginale</term><term>Immunocytome</term><term>Anticancéreux</term><term>Chronique</term><term>Hémopathie lymphoïde B</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose Treatment options for patients with Waldenström macroglobulinemia (WM) and closely related disorders include alkylating agents, purine analogs, and monoclonal antibodies. No large randomized studies have yet been reported comparing any of these approaches. Patients and Methods The randomized WM1 study (Trial Comparing Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia) was undertaken in 101 centers in five countries enrolling 414 eligible patients (339 with WM, 37 with non-mucosa-associated lymphoid tissue marginal zone lymphoma, and 38 with lymphoplasmacytic lymphoma) who were randomly assigned to receive chlorambucil or fludarabine. The primary end point was the overall response rate (ORR). Results On the basis of intent-to-treat analysis, the ORR was 47.8% (95% CI, 40.9% to 54.8%) in the fludarabine arm versus 38.6% (95% CI, 32.0% to 45.7%) in the chlorambucil arm (P = .07). With a median follow-up of 36 months (interquartile range, 18 to 58 months), median progression-free survival (PFS), and duration of response (DR) were significantly improved in the fludarabine arm compared with the chlorambucil arm: PFS, 36.3 versus 27.1 months (P = .012) and DR, 38.3 versus 19.9 months (P < .001). In patients with WM, median overall survival (OS) was not reached in the fludarabine arm versus 69.8 months in the chlorambucil arm (95% CI, 61.6 to 79.8 months; P = .014). Grade 3 to 4 neutropenia was significantly higher among patients treated with fludarabine (36%) compared with patients treated with chlorambucil (17.8%; P < .001). Second malignancies were significantly more frequent in the chlorambucil arm with 6-year cumulative incidence rate of 20.6% versus 3.7% in the fludarabine arm (P = .001). Conclusion In the complete intent-to-treat study population, fludarabine significantly improved PFS compared with chlorambucil, and in patients with WM, it improved OS.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Centre-Val de Loire</li><li>Hauts-de-France</li><li>Midlands de l'Ouest</li><li>Nord-Pas-de-Calais</li><li>Nouvelle-Aquitaine</li><li>Picardie</li><li>Région Centre</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Amiens</li><li>Birmingham</li><li>Bordeaux</li><li>Clermont-Ferrand</li><li>Lens (Pas-de-Calais)</li><li>Melbourne</li><li>Paris</li><li>Tours</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Leblond, Veronique" sort="Leblond, Veronique" uniqKey="Leblond V" first="Véronique" last="Leblond">Véronique Leblond</name></noRegion><name sortKey="Chevret, Sylvie" sort="Chevret, Sylvie" uniqKey="Chevret S" first="Sylvie" last="Chevret">Sylvie Chevret</name><name sortKey="Choquet, Sylvain" sort="Choquet, Sylvain" uniqKey="Choquet S" first="Sylvain" last="Choquet">Sylvain Choquet</name><name sortKey="Dartigeas, Caroline" sort="Dartigeas, Caroline" uniqKey="Dartigeas C" first="Caroline" last="Dartigeas">Caroline Dartigeas</name><name sortKey="Dilhuydy, Marie Sarah" sort="Dilhuydy, Marie Sarah" uniqKey="Dilhuydy M" first="Marie-Sarah" last="Dilhuydy">Marie-Sarah Dilhuydy</name><name sortKey="Lejeune, Julie" sort="Lejeune, Julie" uniqKey="Lejeune J" first="Julie" last="Lejeune">Julie Lejeune</name><name sortKey="Malphettes, Marion" sort="Malphettes, Marion" uniqKey="Malphettes M" first="Marion" last="Malphettes">Marion Malphettes</name><name sortKey="Morel, Pierre" sort="Morel, Pierre" uniqKey="Morel P" first="Pierre" last="Morel">Pierre Morel</name><name sortKey="Nguyen Khac, Florence" sort="Nguyen Khac, Florence" uniqKey="Nguyen Khac F" first="Florence" last="Nguyen-Khac">Florence Nguyen-Khac</name><name sortKey="Royer, Bruno" sort="Royer, Bruno" uniqKey="Royer B" first="Bruno" last="Royer">Bruno Royer</name><name sortKey="Tournilhac, Olivier" sort="Tournilhac, Olivier" uniqKey="Tournilhac O" first="Olivier" last="Tournilhac">Olivier Tournilhac</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Johnson, Steve" sort="Johnson, Steve" uniqKey="Johnson S" first="Steve" last="Johnson">Steve Johnson</name></noRegion><name sortKey="Copplestone, Adrian" sort="Copplestone, Adrian" uniqKey="Copplestone A" first="Adrian" last="Copplestone">Adrian Copplestone</name><name sortKey="Ewings, Maeve" sort="Ewings, Maeve" uniqKey="Ewings M" first="Maeve" last="Ewings">Maeve Ewings</name><name sortKey="Owen, Roger G" sort="Owen, Roger G" uniqKey="Owen R" first="Roger G." last="Owen">Roger G. Owen</name><name sortKey="Patmore, Russell D" sort="Patmore, Russell D" uniqKey="Patmore R" first="Russell D." last="Patmore">Russell D. Patmore</name><name sortKey="Pratt, Guy" sort="Pratt, Guy" uniqKey="Pratt G" first="Guy" last="Pratt">Guy Pratt</name><name sortKey="Rule, Simon" sort="Rule, Simon" uniqKey="Rule S" first="Simon" last="Rule">Simon Rule</name><name sortKey="Willoughby, Sara" sort="Willoughby, Sara" uniqKey="Willoughby S" first="Sara" last="Willoughby">Sara Willoughby</name><name sortKey="Wright, David" sort="Wright, David" uniqKey="Wright D" first="David" last="Wright">David Wright</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Francis Seymour, John" sort="Francis Seymour, John" uniqKey="Francis Seymour J" first="John" last="Francis Seymour">John Francis Seymour</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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